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Moreover, ROS can also abstract hydrogen atoms adjacent to the double bonds of PUFAs to form lipid radicals, which then combine with oxygen to generate lipid peroxyl radicals, further triggering chain reactions [62, 63]

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( d ) NAO staining of mitochondrial mass in HT29 cells treated 5FU for 72 h, n = 3 biological replicates, with mean s.e.m